Packed with 60mg of super potent antioxidant Pterostilbene from the same family of stilbenes as resveratrol. Combined with 200mg of 10:1 blueberry extract to include all of the rest of the medicinal compounds in this beloved berry. As with cannabis providing a full spectrum of compounds from the same source will maximize the utilization and absorption of the Pterestilbene. We take the entourage effect and full spectrum seriously and therefore we believe folding a potent and refined active into a matrix from which it originates makes it even more effective.
Together they will protect telomeres and reduce their shortening. Both promote healthy aging and kickstart mitochondria into optimal metabolic function. Find your NAD+ Nasal Spray here.
Another powerful stilbene antioxidant, from grape skins and Japanese Knotweed. This compound has been shown to be a powerful sirtuin activator which is an epigenetic pathway associated with longevity. It is also an “exercise-mimetic” meaning it can replicate the benefits one gets from an exercise routine, but without lifting a finger (although we highly recommend one). Get it here.
Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE.
It has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the initiation and progression of many diseases through several mechanisms. While there is a wealth of in vitro and in vivo evidence that resveratrol could be a promising therapeutic agent, clinical trials must confirm its potential.
Even more, other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported.
Pterostilbene vs. Resveratrol
Due to two methoxy groups in its skeleton, pterostilbene is more lipophilic than resveratrol and thus possesses higher intestinal permeability and cellular uptake and enhanced stability. Moreover, pterostilbene exhibits less toxicity and fewer adverse effects, providing it with superior potential in cancer chemoprevention and chemotherapy applications. https://pubmed.ncbi.nlm.nih.gov/32064876/
The SIRT1-regulated pathway affects metabolism, stress resistance, cell survival, cellular senescence, inflammation-immune function, endothelial functions, and circadian rhythms. Resveratrol has been shown to activate SIRT1 and therefore is predicted to benefit diseases affected by abnormal metabolic control, inflammation, and cell cycle defects.
Pterostilbene has shown great promise in addressing Alzheimer’s Disease, more so than resveratrol. Most likely due to its lipophilic nature it absorbs better and is probably absorbed into the brain easier. Staving off age related cognitive decline could be greatly helped by the addition of this antioxidant into your regiment.
Pt administration improved performance in behavioral tests and positively affected memory consolidation
The neuroprotective activity of resveratrol and pterostilbene demonstrated in in vitro and in vivo studies suggests a promising role for these compounds in the prevention and treatment of dementia. In comparison to resveratrol, pterostilbene appears to be more effective in combatting brain changes associated with aging.