Water Soluble CBD and Why it’s Not the Best

water The Remedy Co.

     The industry right now is plagued with water soluble nano emulsified product. All of these products have made huge claims of 100 X of rates of absorption. They have fancy assays showing how much CBD reaches the bloodstream. 

     These products sound really good on paper and get everyone really excited, but do they really hold water? There are some pretty big claims surrounding the water soluble nano and we have tried all of the different variations of these ingredients from all different pharmaceutical laboratories and cannabinoid extraction facilities and we’ve got the verdict.

What is water soluble nano?

     It seems that every CBD product manufacture these days has a water soluble product and are willing to say how many times better absorbed and utilized by the body it is than just CBD alone. Yet they don’t have a lot of explanations about what it actually is how it works and why that theoretically makes sense. 


     Even a lot of the ingredient manufacturers that are trying to sell these products to CBD product manufacturing companies don’t offer a whole lot of explanation as to why their ingredient formulation is superior to another. 


     The reason is because there is only minute, if any at all, differences in the water soluble nano emulsified ingredients. Fact is, this technology has been around for a long time (relative to the lifetime of the hemp CBD industry) and the nutraceutical and pharmaceutical space has been utilizing it to “increase the rate of absorption” of oil soluble components ever since it was discovered. 

How do they work?

     The way they work is by first breaking down the active molecules, in this case CBD, into very small particle sizes. That is where the “nano” comes from, “nanotizing” the particles from anywhere between 20 nm to 80 nm, supposedly. 

     This increases the surface area of the active material which is a critical physical characteristic for the next steps in the process. That increased surface area is utilized for encapsulating them in phospholipids. Phospholipids are a type of oil-like compounds which have a hydrophilic head and a lipophilic tail. 

     What you can do with these fancy molecules is you can stick those little lipophilic tails to fat soluble ingredients like CBD was they are naturally attracted to. When the CBD is completely surrounded by the lipophilic side of these phospholipids than the outside of the phospholipids includes only the hydrophilic heads.

Hydrophilic What?

     These hydrophilic heads are much more compatible and comfortable in an aqueous phase and what that means is that they are more accepting of water surrounding them. This is a very clever trick that the body uses in order to separate cells and isolate the watery interior with the liquid based membranes surrounding them while also allowing certain things to pass through, creating the semi permeable membranes that surround cells. 

     Then a surfactant is added to the water that softens the water lowering the surface tension and making it more accepting of the oil ingredients that it would normally reject. CBD and cannabinoids in general are normally very hydrophobic. 

     Even if you dissolve CBD or THC in alcohol where it fully dissolves but then you introduce that alcohol to water the cannabinoids will reject from the water very forcefully and turn into a gum where they’ll sit on top of the water jumping around, like trying to touch together two negative poles of a magnet. 

     The cannabinoids in the water run away from each other pushing each other away with a force very similar to magnetism. So to get these molecules to play nice together it takes a series of steps where is the process I’m describing. But as you can imagine there is a number of hurdles and the result is often underwhelming.

The Reality of these Emulsions

     Often the final form of these emotions is a lot less miraculous than one might imagine from overcoming these strong forces in the relationship between Cannabinoids and Water. There’s several qualities to a water soluble nano formulation and none of them have it all. 

     Many of them are cloudy as emulsions usually are because there are quite literally spheres suspended in the water not fully dissolved but just dispersed throughout the water. They can be seen by the naked eye in a way which could be off-putting. 

     Those same spheres dispersed throughout the water can have a displeasurable taste which nobody appreciates. Often the water can deliver this oil onto the back of your throat where is sticks and does not continue down, leaving you with an awful textured tickle in your throat and irritation from something that will not go down easy or absorb well in that spot.

What about the stability and shelf-life?

     The shelf-life of these types of extracts is also in question and often when left to their own devices will settle or rise in some kind of way which is very similar to the rejected CBD which I described earlier, gum sitting on top of the surface of the water which is rejecting it. 

     So not only do all of these issues lead to trade-offs and issues that are normally absent in CBD products or extracts but having multiple of these issues arise within a single type of Nano emulsified CBD. Of course the makers of these ingredients will never admit to any of this and don’t want to acknowledge the lacking of what they produced. 

     These numerous drawbacks in and of them selves normally would not be enough to deter us from using a particular ingredient if it were so effective. But is it really that effective?

10 or 100x Better Absorbed?

     If a 10 times or 100 times absorption were possible regardless of taste, texture, visual stimuli, or otherwise we will be utilizing such an ingredient. Anything where 1 mg could be consumed and the effects of 10 or 100 mg are we felt would change the game and we would be compelled to use such a thing too, matter what our feelings on the particularities of the sensory stimuli that product were. 

     Our bedrock is always first principles if we feel in our own use that something is affective we will use it but if we don’t find that thing to be very effective in our experience and use, then we will not. I personally have not felt the effects from any water soluble extract that I have ever tried, not one of these nano emulsified CBD extracts. 

     I’ve taken upwards of 100 mg of these extracts that supposedly should simulate the effects of 1000mg if not 10,000mg of oil based CBD and barely felt anything but a tease at all. And in the end there is only what we perceive from these ingredients as far as how effective it is. 

     I don’t care what the assays say about the amount of CBD that ends up in my bloodstream I am going to use my own sense and feelings as a main determining factor for me evaluating effectiveness of any ingredient that I’m thinking about using. I’m not denying the truth of the assays in anyway. They could completely be right about there being 10, or 100, or 1000 times the amount of CBD in the bloodstream but that doesn’t necessarily mean that it’s supposed to be.

CBD in the Bloodstream, Is that Even Where we Want It?

     There is nothing to suggest that forcing greater amounts of CBD into the bloodstream will increase its effectiveness. Actually, there is a lot of evidence that fat soluble compounds are carried by the lymphatic system and not primarily by the bloodstream. 

     As usual what we are able to test and measure, easily and simply, in the systems that we as the science and medical world focus on evaluating and understanding are the only things that we think matter. The physiological systems that we don’t understand well, and cannot measure well, slip through the cracks and get disregarded as unimportant. 

     Well just because we deem something unimportant and turn a blind eye to it does not mean that it is the case. And just because we figure out how to jam 10 times more of something into our bloodstream doesn’t mean that’s where it’s supposed to go or is inherently going to be more effective.

After Thousands of years of use, the body knows what to do with oils

Fats are one of the most important parts of any diet. Terpenes are precursors to hormones. Fats get incorporated as myelin sheaths that protect neurons and get incorporated into cell walls the protect cells from intruders. Our brains are comprised of fats fats by a large majority. 

     Without fats our hormones systems get destroyed our neurological system is laid to ruins and we will be crippled. Our bodies are not confused when it comes to fats and how to utilize them. If anything we are confused when it comes evaluating how the body absorbs fats and utilizes lipophilic compounds. 

     As usual modern science and the medical system thinks that there is a problem with the processes millions of years of evolution have developed. They think that now if a few short years of research they know better about where to shove the CBD, for sure. I highly doubt that the confusion lies with millions of years of evolution, and think it’s much more likely that we just have an incomplete understanding of our lipid metabolism. 

     What that means to me is that people have been eating hemp or eating meat with fats that have Cannabinoids from hemp stored up in them for tens of thousands if not hundreds of thousands of years. In that time there was no laboratories producing water soluble nano preparation’s of these cannabinoids they are absorbed by the fat of these animals and absorbed through their gut lining in the air bodies as well.

First principles comparison of water soluble vs oil

     When using a nano emulsified CBD product I personally find that I do feel a slight inkling of onset very quickly after consumption. Each time I think, “maybe this is the moment where my concerns will be assuaged and my expectations will be rebuked, yeah but oh no, every single time that feeling fades almost immediately and leaves me with nothing but wanting.

     I don’t seem to get any lasting benefit and if anything it seems like my body clears out this CBD incredibly quickly and leaves nothin of benefit behind. Of course even that amount of feeling is probably more than most people expect from any sort of natural health product, with all the snake oil salesman that are so prolific within the space. 

     Well formulated CBD products like our full spectrum tinctures or specialty tinctures that include a number of the absorption and enhancing ingredients specifically to assist in the bodies digestion and absorption of oils it might take five or 10 minutes longer to feel the first onset of effects. 

     That is still significantly faster than most oil based products on the market which take about 30 or 45 minutes, if you ever feel anything at all, but it’s not the one to five minutes like the water soluble. Luckily it’s not just a tease and that’s just the beginning. With normal CBD properly formulated that feeling last 4 to 8 hours after the first onset of effects which is significant and practical.

     When you’re taking a health product you want noticeable effects for as long as possible, that’s where you get bang for your buck. If you have to constantly re-dose in order to get any sort of noticeable effects from it, that’s a product that you’re going to blow through very quickly.

Is there a Way to Make a Water-Soluble Extract?

     There is one way to make a water soluble extract that I find acceptable and effective. And that is by an ethanol extraction of hemp flower. While a CBD extract dissolved in alcohol will reject from water I have found that a flower extraction directly in the ethanol will for some reason stabilize those cannabinoids within the alcohol and not allow them to reject. 

     Maybe a hard-core chemist can comment on the physics of how that works, but I am not completely aware of them. This is the same method that herbalists and shaman have been using for tens of thousands of years to make herbal tinctures that they have found effective. 

     They have been used as medicine for eons, since the dawn of time . That means that the entire historic use of cannabinoids there’s been two primary modes of consumption; one ingesting the cannabinoids as they are or absorbed into a oil based concoction, whether that’s food, whether that’s the fat of the animal, or eating the flower directly in it’s waxy oil form on the bud people and animals alike have done so and it’s been effective for them because they continue to do so and revere this plant.

Long History of Alcohol Extracts

     Outside of that alcohol tinctures have been derived from cannabis and used as medicine which is well documented by modern antique glass bottles early American tinctures all the way back to thousands of years ago in Chinese medicine texts describing its use in a number of instances. 

     These simple traditional use cases are what I personally have found to be the most effective and they also outlined the same underlying principles that evolution nature and our ancestors no best. The priorities of today are more centered around hyper-novelty and creating new “complex” marketable ingredients which you can’t do or make at home and you are all not “smart enough“ to fully understand how they work or why they make sense. And this way they can leave you in the dark “trusting the science” and ensuring that you’re in good hands in the hard-working doctors or whatever.

     If there is one thing that I am good at, I have a knack for trusting my gut and knowing what substances are good, what things feel good to me or not, evaluating different substances regardless of assays or lack there of. With this talent I’ve developed my line of different natural health products that we find effective for all sorts of different things. I can’t allow myself to be seduced by these paper assays erroneous ways of evaluating these nano emulsified CBD ingredients that report them as being superior. 

     They may allow infinite CBD to get into your bloodstream, that’s not necessarily where it supposed to be, and that isn’t where it’s been for the entirety of an evolutionary process. We don’t even really know where it is supposed to go to be most effect or how it even works for that matter.

Can they really be full spectrum?

     Another huge downside is the question of whether an emulsified CBD can really even be full spectrum. The industry CBD and users alike have all accepted from their own use and experimentation that full spectrum CBD preparation‘s are superior in their effectiveness to an isolate. 

     But when you break down CBD into a nano size particle and then dilute it with the emulsifiers and surfactants it becomes only about 20% on average sometimes 10 or 15% in potency. This also is a 80 or 90% reduction in minor cannabinoids which are already usually only available in such minute quantities they can barely be called full spectrum in the first place. 

     So can nano emulsified cannabinoid preparation‘s really be even called full spectrum in any case if you start off with 3% CBG in your full spectrum distillate and you reduce that by 90% and you’re left with the smallest fraction imaginable. Once the supporting cannabinoids are reduced down to such an incredibly small quantity the results can only be considered homeopathic, if anything.

Keeping Homeopathic Medicine in Mind

     Homeopathic medicine is based on the theories of essentially taking medication and diluting them down to the point where they can’t be detected by any sort of equipment and then they’re called medicine. This is essentially the same process of nano emulsified CBD especially when it comes to the minors and the CBD that still get used to refer to an ingredient as full spectrum. 

     I think the possibility of that being actually full-spectrum in any sort of way is laughable at best. The amount of processing involved in arriving at these preparation‘s is massive. Whole point of full spectrum is that the extract is minimally processed and left largely intact to be representative of the plant. These water soluble extracts are the most processed forms of CBD.

Did you leave big pharma behind just to re-pharma your canna?

     And that leaves me with my last point. If you were looking for a more natural way to ease your suffering, why are you going to take that thing in which you are seeking solace with and apply the same processes and techniques as the industry which lost your faith and you were running from? Most people use CBD because they have either been failed by the medical system, they don’t trust the pharmaceutical companies which produce risk laden drugs and they are looking for alternatives. 

     If you’ve already come to those conclusions why would you turn around and choose the version of that alternative which is most similar to that which you are looking to replace. I understand that the glitz and glam that you have been conditioned to be impressed by. 

     The nonstop marketing of the superiority of modern science to traditional practices is ceaseless. But if you were finding that some of these modern medicines have underserved you then perhaps it is best to approach your Health from an entirely different angle.

Nature Doesn't Make Mistakes

     Nature doesn’t make mistakes, nature is everything around us. Science is only the observation of nature and the utilization or manipulation of those systems which we’ve just begun to understand. We are not in a position to know better or out-smart nature, and if we ever think that we are, you gonna rest assured that it is hubris fueling such a thought. 

     So when you see someone marketing something to you saying that they found a better way than your body has done for thousands of years, think twice about the validity of such a statement. Evaluate whether you think this one individual human being is likely to have out-smarted nature and evolution and everything it has successfully created that functions so well together or if maybe they are just trying to market you the latest thing that sounds great but has no value at all and if anything is perhaps worse than the way things were always done.

How does The Remedy Co. maximize absorption?

     What we do at the remedy is harness time tested mechanisms which maximize the efficacy of oil based lipophilic compounds. Turmeric has been used for thousands of years for its variety of healing benefits, and with that black Pepper has always been a primary recommendation. 

     Modern scientific research has also substantiated the fact that black pepper and the piperine contained within potentiate the absorption of the curcumin within turmeric by 2000%. Curcumin just happens to be a waxy lipophilic curcuminoid, Note the oid, conspicuously similar to cannabinoid in the nomenclature as well as with its waxy lipophilic nature. 

     The Remedy utilizes Black pepper to leverage its absorption enhancing properties which we believe applies to all lipophilic compounds. We don’t use an isolated piperine in which it has been denatured and extracted with petroleum solvents so harsh that it is but a glimmer of what it was once, held within a black peppercorn. Full spectrum is something we take so seriously, that we hold the principles down to each individual ingredient.

Here comes the Full Spectrum

     We use the only full spectrum black pepper extract in the entire world. The only CO2 extracted black pepper that gets produced in the world, which not only includes piperine to help with absorption but also includes guineensine which acts as an endo-cannabinoid re-uptake inhibitor and actually simulate CBDs mechanisms of action while allowing CBD to act longer within the central nervous system. 

     Piperine can actually be harmful to the gut lining if isolated and processed but when held within the matrix of compounds that it was originally placed within in a black peppercorn is incredibly medicinal. So you should be very aware when your products sell you on things like bio-Perrine or piperine extracts isolated to a 95 percentile concentration when that concentration of piperine is actually harmful to your body. Once again this is a hyper novel form of a natural compound that your body is not used to dealing with and can be harmful.

Sunflower Lecithin Brings it to the Next Level

     We also utilize, in our particular case, sunflower lecithin in order to help oil bind to the water. In our case we use it in an oil formulation so that oil can be better absorbed by your body which is mostly water. It is also going to help that oil be more compatible with your cell membranes, like the cell membranes of your gut lining. 

     Instead of utilizing that lecithin to place the oil soluble CBD within water and therefore potentially confuse the body as to what it’s actually trying to digest, undermining the enzymatic processes that would normally be triggered by a fat soluble ingredient entering the mouth in the stomach. We lower the barrage identify the oil for what it is what include some compounds what is the value would also use in order to digest as a thing.

But Wait, There's More

     We also use oil of cinnamon CO2 extracted which helps augment the lipid metabolism within the gut. If your lipid metabolism and digestion is augmented that’s going to further increase the body‘s ability to absorb and utilize CBD as well. 

     This is just one more example; rather than undermining the bodies usual process and pretending that we know better, simply observing how the body does things normally offering it things were supplement that process. This is how science has always been done and how it will continue to be done successfully into the future. 

     Simply a matter of observing nature, understanding a minute portion of that process and taking that my new understanding and using it to discover mechanisms which augment the process that is already occurring. This is how we have developed the most effective line of tinctures on the market and why we do not use water soluble nano which is just Aline imprint of pharmacological technology yet untested unconfirmed but push through the pipeline nonetheless. We will wait until our personal experience confirms what are the pencil pushers paper assays try and imply.

Don't Believe the Hype

So, don’t believe the hype, go with what is tried and true.  Try any of The Remedy Co’s tinctures and see for yourself.  Go ahead, compare our tinctures to any water soluble CBD tincture on the market and let us know what you think.


Bioavailability enhancers of herbal origin: An overview

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